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纈草根 메탄올 추출물이 고지혈증 유발 생쥐의 지질대사에 미치는 영향
Effects of Valerianae Radix et Rhizoma Methanol Extract on High-fat Diet-induced Hyperlipidemic Mice
J Korean Med Obes Res 2020;20:88-96
Published online December 31, 2020;  https://doi.org/10.15429/jkomor.2020.20.2.88
Copyright © 2020 The Society of Korean Medicine for Obesity Research.

박선미⋅김영균⋅유선애1⋅조성우2⋅이명화⋅임재은3⋅김경민
Sun Mi Park, Young Kyun Kim, Sun Ae Yu1, Sung Woo Cho2, Myeong Hwa Lee, Jae Eun Lim3, Kyoung Min Kim

동의대학교 한의과대학 한방내과, 1한방소아과, 2한방재활의학과, 3침구의학과

Department of Internal Medicine, College of Korean Medicine, 1Department of Pediatrics, College of Oriental Medicine, Departments of 2Korean Rehabilitation Medicine of Korean Medicine, 3Acupuncture & Moxibustion Meridian & Acupoint, College of Korean Medicine, Dong-Eui University
Kyoung Min Kim
Department of Internal Medicine, College of Korean Medicine, Dong-Eui University, 62 Yangjeong-ro, Busanjin-gu, Busan 47227, Korea
Tel: +82-51-850-8623
Fax: +82-51-867-5162
E-mail: kyoung@deu.ac.kr
Received October 31, 2020; Revised November 19, 2020; Accepted November 23, 2020.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives: This study was designed to investigate the effects of Valerianae Radix et Rhizoma Methanol Extract (VRME) on serum lipid levels in a high-fat diet-induced hyperlipidemic mice.
Methods: Each 8 C57BL/6 mice were randomly assigned to normal diet group, high-fat diet control group, high-fat diet plus 100 mg/kg/day of VRME group. In order to induce hyperlipidemia, high-fat diets were supplied to control group and VRME group for four weeks. Normal diet group were supplied with general feed for four weeks. After that control group supplied only high-fat diets as feed, VRME group received oral administration of VRME with high-fat diets for three weeks. and normal diet group were supplied with general feed for three weeks. After seven weeks, the changes in the body weight, the plasma levels of total cholesterol, triglyceride, high density lipoprotein-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose in serum were measured.
Results: In our results, VRME did not affects weight gain, serum AST and ALT in high-fat diet-induced hyperlipidemic mice. Oral administration of VRME lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. and oral administration of VRME lowered blood glucose significantly.
Conclusions: These results suggest that VRME could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.
Keywords : Valeriana fauriei Briquet, Valerianae Radix et Rhizoma, Hyperlipidemias


December 2020, 20 (2)
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