search for




 

고지방식이 유도 비만 마우스에서 창출, 지모, 육계, 목단피 혼합추출물의 항비만 및 항당뇨 효능 연구
Antiobesity and Antidiabetic Effects of Polyherbal Extract with Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in High Fat Diet-induced Obesity Mice
J Korean Med Obes Res 2020;20:69-77
Published online December 31, 2020;  https://doi.org/10.15429/jkomor.2020.20.2.69
Copyright © 2020 The Society of Korean Medicine for Obesity Research.

정수민1†⋅설영현1†⋅전가윤1⋅박민하1⋅유이1⋅강석용2⋅박용기1,2⋅정효원1,2
Su Min Jung1†, Young Hyun Seol1†, Ka Yoon Chun1, Min Ha Park1, Yi Liu1, Seok Yong Kang2, Yong-Ki Park1,2,Hyo Won Jung1,2

1동국대학교 한의과대학 본초학교실, 2동국대학교 한방신약개발센터

1Department of Herbology, College of Korean Medicine, Dongguk University, 2Korean Medicine R&D Institute, Dongguk University
Yong-Ki Park
Department of Herbology, College of Korean Medicine, Dongguk University, Dongdaero 123, Gyeongju 38066, Korea
Tel: +82-54-770-2647
Fax: +82-54-770-2647
E-mail: yongki@dongguk.ac.kr

Hyo Won Jung
Department of Herbology, College of Korean Medicine, Dongguk University, Dongdaero 123, Gyeongju 38066, Korea
Tel: +82-54-770-2647
Fax: +82-54-770-2647
E-mail: tenzing2@hanmail.net
Received October 28, 2020; Revised November 22, 2020; Accepted December 4, 2020.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives: In this study, we investigated the antiobesity and antidiabetic effects of polyherbal extract, DM2 consisting of Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in high fat diet-induced obesity mice.
Methods: DM2 extract was prepared with a hot water. Six-week-old male C57BL/6N mice were fed a high-fat diet (HFD) for 8 weeks and then administrated with DM2 extract (500 mg/kg, p.o.) for 4 weeks. The changes of physiological markers, body weight (BW), food and water intakes, and the levels of fasting blood glucose (FBG) were measured once a week for 4 weeks in mice. The the serum levels of glucose, insulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (T-CHO), triglyceride, and low density lipoprotein cholesterol in sera were measured in mice using autometic chemical analyzer and enzyme linked immunosorbant assay. We also observed the histological changes of liver and pancreatic tissues with Hematoxylin & Eosin staining.
Results: In physiological change, the increases of BW, calorie intake, and FBG in HFD-induced obese mice were significantly decreased after administration of DM2 extract for 4 weeks. The decrease of water intake was significantly increased in DM2 extract-administrated mice. In serological change, the administration of DM2 extract in obesity mice was significantly decreased the serum levels of glucose, insulin, T-CHO, AST, and ALT levels. We also found that DM2 extract inhibited the increase of lipid droplets in liver and the structural destruction of pancreatic tissues in obesity mice.
Conclusion: Our study demonstrated that DM2 extract has antiobesity antidiabetic effects with body weight loss, decrease of glucose and insulin levels, and lipid accumulation on liver tissue.
Keywords : Obesity, Diabetes mellitus, High-fat diet, Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi cortex, Moutan radicles cortex


December 2020, 20 (2)
Full Text(PDF) Free


Cited By Articles
  • CrossRef (0)

Funding Information