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대사증후군 개선을 위한 뽕잎, 오디, 누에 분말의 혼합 비율 최적화
Optimization of Mixing Ratio of Mulberry Leaf, Mulberry Fruit, and Silkworm for Amelioration of Metabolic Syndrome
J Korean Med Obes Res 2018;18:83-95
Published online December 30, 2018;  https://doi.org/10.15429/jkomor.2018.18.2.83
Copyright © 2018 The Society of Korean Medicine for Obesity Research.

김민주, 김현숙1, 김애정
Min-Ju Kim, Hyun-Sook Kim1, Ae-Jung Kim

경기대학교 대체의학대학원, 1경기대학교 대학원 대체의학과

Graduate School of Alternative Medicine, Kyonggi University, 1Department of Alternative Medicine, Graduate School of Kyonggi
University
Ae-Jung Kim
Graduate School of Alternative Medicine, Kyonggi University, 24 Kyonggidae-ro 9-gil, Seodaemun-gu, Seoul 03746, Korea, Tel: +82-2-390-5044, Fax: +82-2-313-4131, E-mail: aj5249@naver.com
Received November 3, 2018; Revised November 28, 2018; Accepted December 7, 2018.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives: The aim of this study was optimized mixing ratio of mulberry leaf, mulberry fruit, and silkworm for amelioration of the metabolic syndrome by using response surface method (RSM).
Methods: Antioxidant, antidiabetic and antihypertensive activities of fifteen mixed powder of mulberry leaf, mulberry fruit, and silkworm by RSM were measured as indicators of metabolic syndrome.
Results: The optimal mixing ratio of mulberry leaves, mulberry fruits, and silkworm with the greatest antioxidant, antidiabetic and antihypertensive activities was as follows: 2.5890 of mulberry leaf (A), 0.1222 of mulberry fruit (B), 2.9999 of silkworm (C). At this time, it was predicted that the total polyphenol content was estimated to be 185.51 tannic acid equivalent mg/g, 1, 1-diphenyl-2-picrylhy drazyl radical scavenging activity 84.77%, 1-deoxynojirimycin content 415.66 mg/100 g, α-glucosidase inhibitory activity 64.31%, γ-aminobutyric acid content 267.77 mg/100 g, potassium content 1,899.11 mg/100 g, and angiotensin-converting- enzyme inhibitory activity was estimated to be 73.78%.
Conclusions: It was concluded that the significant effect of the mulberry leaf, mulberry fruit, and silkworm on the metabolic syndrome-related biological activity indices (antioxidant activity, antidiabetic activity and antihypertensive activity) was as follows: 2.5890 of mulberry leaf (A), 0.1222 of mulberry fruit (B), 2.9999 of silkworm (C).
Keywords : Mulberry leaf, Mulberry fruit, Silkworm, Metabolic syndrome, Optimization, Response surface methodology (RSM)


December 2018, 18 (2)
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