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흰쥐의 알코올 유발성 간손상에 실비음(實脾飮)이 미치는 보호 효과
The Protective Effects of Silbi-um Extract on the Alcoholic Liver Injury in Rats
J Korean Med Obes Res 2018;18:74-82
Published online December 30, 2018;  https://doi.org/10.15429/jkomor.2018.18.2.74
Copyright © 2018 The Society of Korean Medicine for Obesity Research.

김범회
Bum Hoi Kim

동의대학교 한의과대학 해부학교실, 동의대학교 한의학연구소

Department of Anatomy, College of Korean Medicine and Research Institute of Oriental Medicine, Dong-Eui University
Bum Hoi Kim
Department of Anatomy, College of Korean Medicine, Dong-Eui University, 52-57 Yangjeong-ro, Busanjin-gu, Busan 47227, Korea,
Tel: +82-51-850-7411, Fax: +82-51-853-4036, E-mail: bume@deu.ac.kr
Received November 2, 2018; Revised November 9, 2018; Accepted November 11, 2018.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives: The objective of this study is to investigate the effects of Silbi-um (SBU) extract on the alcoholic fatty liver induced by EtOH administration for 8 weeks.
Methods: Male Sprague Dawley rats were used. All animals were randomly divided into 3 groups; Normal, EtOH and EtOH+SBU. The rats of EtOH group were daily treated with ethanol of 25% (v/v) for 8 weeks (n=10). EtOH+SBU group was orally treated with SBU water extract after ethanol administration (n=10). The rats of Normal group were treated with saline (n=10). After 8 weeks, the mean body weight, liver weight, and liver-body weight ratio were calculated. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of all groups were measured. The morphological alterations were observed using hematoxylin and eosin (H&E) and Oil Red O staining. Moreover, the alteration of tumor necrosis factor-α (TNF-α) levels were analyzed immunohistochemistrically.
Results: The histological data showed that liver sections from EtOH group displayed severe steatosis. SBU extract significantly inhibited the progression of the alcoholic liver injury. The increased serum level of ALT and AST induced by ethanol administration were decreased by SBU extract. Furthermore, SBU extract significantly decreased the liver concentrations of TNF-α.
Conclusions: SBU water extract attenuated the alcohol induced fatty liver by improving hepatic lipid metabolism via suppression of TNF-α protein. SBU could be effective in protecting the liver from alcoholic fatty liver.
Keywords : Alcoholic fatty liver, Silbi-um, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Tumor necrosis factor-α (TNF-α)


December 2018, 18 (2)
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