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대청룡탕이 비만 유도 흰쥐의 체중 감량과 혈중지질농도 개선에 미치는 영향
The Effects of Daecheongryoung-tang on Anti-weight Gain and Anti-hyperlipidemic in Obese Sprague Dawley Rat Induced by High Fat Diet
J Korean Med Obes Res 2018;18:27-35
Published online June 30, 2018;  https://doi.org/10.15429/jkomor.2018.18.1.27
Copyright © 2018 The Society of Korean Medicine for Obesity Research.

조은진, 양승정1, 조성희1
Eun Jin Cho, Seung Jeong Yang1, Seong Hee Cho1

남가람한의원, 1동신대학교 한의과대학 한방부인과학교실

Namgaram Korean Medicine Clinic, 1Department of Korean Gynecology, College of Oriental Medicine, Dongshin University
Seung Jeong Yang
Namgaram Korean Medicine Clinic, 24 Geumsansunhwan-ro, Geumsanyeon, Jinju 52625, Korea
Tel: +82-61-330-3502
Fax: +82-61-330-3519
E-mail: cigipus@dsu.ac.kr
Received April 30, 2018; Revised June 25, 2018; Accepted June 25, 2018.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives: The aim of this study is to investigate the effects of Daecheongryoung–tang (DCR) therapy on body weight, serum total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglyceride, free fatty acid, total lipid, phospholipid level and complete blood cell count of obese rats.
Methods: 34 rats are divided into 4 groups, the rats in the normal group are 7 and the rats in the other group are 9 per group; Normal group (general fat diet and no medication), Control group (high-fat diet and no medication), DCR_L group (high-fat diet and DCR 250 mg medication) and DCR_H group (high-fat diet and DCR 500 mg medication). DCR is administrated for 6 weeks.
Results: There is significant statistical difference between Control group and DCR-H group for the body weight, the total cholesterol, LDL cholesterol, triglyceride, free fatty acid level. Also, there is significant statistical difference among Control group, DCR_L group and DCR_H group for body weight, triglyceride, free fatty acid and phospholipid level.
Conclusions: These results suggest that medication of DCR_L and DCR_H is effective for the treatment of obesity.
Keywords : Obese mice, Herbal medicine, Mice, Obesity, Overweight, Cholesterol


June 2018, 18 (1)
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