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알코올로 유도된 흰쥐의 간 지방 형성에 황금 추출물이 미치는 효과
The Effects of Scutellaria Radix Extract on the Alcohol-Induced Fatty Acid Synthesis of Liver in Rats
J Korean Med Obes Res 2018;18:19-26
Published online June 30, 2018;  https://doi.org/10.15429/jkomor.2018.18.1.19
Copyright © 2018 The Society of Korean Medicine for Obesity Research.

김범회
Bum Hoi Kim

동의대학교 한의과대학 한의학과, 동의대학교 한의학연구소

Department of Anatomy, College of Korean Medicine and Research Institute of Oriental Medicine, Dong-Eui University
Bum Hoi Kim
College of Korean Medicine, Dong-Eui University, 52-57 Yangjeong-ro, Busanjin-gu, Busan 47227, Korea
Tel: +82-51-850-7411
Fax: +82-51-853-4036
E-mail: bume@deu.ac.kr
Received April 27, 2018; Revised May 18, 2018; Accepted May 23, 2018.
cc This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives: Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis. The objective of this study is to investigate the effects of Scutellaria Radix (SR) extract on the alcoholic fatty liver induced by long-term EtOH administration.
Results: Male Sprague Dawley rats were used in this study. All animals were randomly divided into Normal group, treated with saline (n=10); EtOH group, treated with ethanol (n=10); EtOH+SR group, treated with ethanol+Scutellaria Radix extract (n=10). For oral administration of ethanol in EtOH and EtOH+SR group, the ethanol was dissolved in distilled water in concentrations of 25% (v/v). Throughout the experiment of 8 week, the rats were allowed free access to water and standard chow. Sample group were administrated by Scutellaria Radix extract daily for 8 weeks.
Results: The levels of hepatic marker such as aspartate aminotransferase and alanine aminotransferase were altered. Histopathological changes such as ballooning, fatty and hydropic degeneration were reduced and the expression of tumor necrosis factor-α (TNF-α) was significantly attenuated by Scutellaria Radix extract.
Conclusions: These data suggest that Scutellaria Radix extract attenuated the alcoholic simple fatty liver by improving hepatic lipid metabolism via suppression of TNF-α protein. Scutellaria Radix could be effective in protecting the liver from alcoholic fatty liver.
Keywords : Alcoholic fatty liver, Scutellaria Radix, TNF-α, AST, ALT


June 2018, 18 (1)
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