Compare Table of Physiological Parameter Between Baseline and 2 Weeks, 4 Weeks After of Non-AE Group
| Parameter | Visit 0 | Visit 2 (2 weeks) | Visit 3 (4 weeks) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-AE group | Item | Mean | Standard deviation | Mean | Standard deviation | P-value | Mean | Standard deviation | P-value | ||
| Pulse waveform | h1 (gf) | 249.2 | 64.2 | 264.5 | 65.8 | 0.306 | 253.4 | 57.0 | 0.757 | ||
| h3 (gf) | 162.4 | 58.6 | 164.1 | 50.0 | 0.888 | 159.6 | 48.2 | 0.820 | |||
| h4 (gf) | 99.3 | 39.3 | 94.3 | 34.9 | 0.558 | 90.3 | 35.1 | 0.288 | |||
| h5 (gf) | 110.3 | 37.0 | 101.8 | 33.2 | 0.297 | 101.1 | 31.9 | 0.245 | |||
| t1 (ms) | 153.7 | 12.8 | 148.5 | 12.9 | 0.079 |
150.4 | 14.5 | 0.285 | |||
| t3 (ms) | 278.7 | 32.4 | 273.6 | 17.6 | 0.398 | 270.9 | 20.2 | 0.211 | |||
| t4 (ms) | 382.8 | 31.3 | 373.2 | 22.1 | 0.124 | 372.4 | 23.9 | 0.103 | |||
| t5 (ms) | 463.5 | 36.7 | 442.0 | 29.8 | 0.007 |
442.5 | 25.7 | 0.005 |
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| h4/h1 (%) | 39.8 | 11.8 | 36.6 | 13.3 | 0.266 | 36.3 | 13.1 | 0.220 | |||
| RAI (%) | 65.7 | 15.0 | 63.2 | 15.0 | 0.470 | 63.4 | 14.2 | 0.491 | |||
| RAI@75 (%) | 72.5 | 22.6 | 63.1 | 22.2 | 0.072 |
62.8 | 19.3 | 0.047 |
|||
| t1/t (%) | 18.05 | 2.91 | 19.42 | 2.62 | 0.034 | 19.8 | 2.26 | 0.019 | |||
| t3/t (%) | 32.39 | 4.77 | 35.76 | 4.26 | 0.002 |
35.0 | 3.70 | 0.008 | |||
| t4/t (%) | 44.79 | 6.45 | 48.89 | 6.23 | 0.006 |
48.4 | 5.60 | 0.010 |
|||
| w (ms) | 200.6 | 46.0 | 218.0 | 49.6 | 0.118 | 215.8 | 39.5 | 0.125 | |||
| w/t (%) | 23.97 | 7.42 | 28.47 | 6.68 | 0.007 |
27.98 | 5.34 | 0.008 |
|||
| Pulse characteristic | Pulse rate (bpm) | 70.5 | 11.3 | 78.7 | 11.4 | 0.003 |
77.85 | 9.02 | 0.002 |
||
| Applied pressure (gf) | 141.4 | 30.1 | 141.0 | 30.1 | 0.963 | 143.4 | 31.6 | 0.777 | |||
| Systolic area (㎏f/㎠) | 14.3 | 3.9 | 14.5 | 3.5 | 0.756 | 14.0 | 3.5 | 0.742 | |||
| Pulse area (㎏f/㎠) | 21.8 | 6.8 | 20.3 | 5.7 | 0.311 | 19.7 | 5.3 | 0.130 | |||
| Pulse width (㎏f/㎠) | 11.6 | 3.3 | 12.3 | 3.9 | 0.392 | 11.5 | 3.1 | 0.847 | |||
| Hemodynamic | SV (mL) | 89.0 | 14.8 | 81.0 | 12.4 | 0.013 |
81.3 | 10.5 | 0.011 |
||
| SVI (mL/m3) | 55.21 | 9.27 | 50.64 | 8.03 | 0.025 |
50.7 | 6.91 | 0.018 |
|||
| CO (L) | 6.1 | 0.7 | 6.2 | 0.6 | 0.449 | 6.2 | 0.6 | 0.433 | |||
| SVRI (dyn⋅s⋅cm-5⋅m2) | 1,637 | 268 | 1,665 | 223 | 0.620 | 1,676 | 224 | 0.488 | |||
| SBP (mmHg) | 103.8 | 13.0 | 107.3 | 12.2 | 0.223 | 107.3 | 12.2 | 0.219 | |||
| DBP (mmHg) | 69.9 | 10.4 | 73.79 | 9.77 | 0.096 |
74.13 | 9.03 | 0.059 |
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| MBP (mmHg) | 81.2 | 10.2 | 85.03 | 9.45 | 0.090 |
85.17 | 8.4 | 0.062 |
|||
| Body | Weight (kg) | 58.14 | 8.97 | 57.24 | 8.82 | 0.661 | 57.44 | 8.97 | 0.732 | ||
| Temperature (℃) | 36.9 | 0.67 | 36.7 | 0.65 | 0.264 | 36.9 | 0.45 | 0.979 | |||
| Muscle mass (kg) | 21.26 | 3.05 | 20.93 | 2.94 | 0.626 | 21.10 | 2.90 | 0.804 | |||
| Body fat mass (kg) | 18.71 | 6.09 | 18.42 | 5.78 | 0.831 | 18.35 | 5.59 | 0.785 | |||
| BMI (kg/m2) | 21.93 | 3.0 | 21.61 | 2.95 | 0.637 | 21.64 | 2.93 | 0.669 | |||
AE: adverse event, RAI: Radial Augmentation Index, SV: stroke volume, SVI: stroke volume Index, CO: cardiac output, SVRI: systemic vascular resistance index, SBP: systolic blood pressure, DBP: diastolic blood pressure, MBP: mean blood pressure, BMI: body mass index.
*Mark for significant change or observed trend in data.
