Journal of Korean Medicine for Obesity Research : eISSN 2288-1522 / pISSN 1976-9334

Table. 1.

Table. 1.

Summary of the Included Studies

1st Author Subject Intervention Measuring indicators
Animal Sex/Age (w) Inducing methods Herbal material Positive control Period (w) Macro-scopic Bio-chemical Micro-scopic Molecular
Suh DH11) C57BL/6J mouse -/7 HFD Dolichos lablab L. Milk thistle 9 ○ ○ ○
Kwan HY12) C57BL/6 mouse M/5 HFD Cinnamomum cassia - 15 (d) ○ ○ ○
Yang Q13) C57BL/6 mouse M/6 HFD Plantago asiatica L. Seeds - 2 ○ ○ ○ ○
Zhong T14) KM mouse F/5 HFD Angelica sinensis - 4 ○ ○ ○
Choi JY15) C57BL/6J mouse M/4 HFD Taeeumjowui-tang: Coicis Semen, Castaneae Semen, Raphani Semen, Schizandrae Fructus, Platycodi Radix, Radix Ophiopogonis, Acori Graminei Rhizoma, Ephedrae Herba - 12 ○ ○ ○ ○
Jung HW16) C5BL/6 mouse M/5 HFD Pueraria lobata Metformin 16 ○ ○ ○ ○
Song MY17) C57BL/6 mouse M/6 HFD Cinnamomum cassia Metformin 16 ○ ○ ○ ○
Song MY18) C57BL/6 mouse M/5 HFD CAPA: Cinnamomum cassia Blume, Atractylodes macrocephala Koidzumi, Pueraria lobata Benth, Aconitum carmichaeli Debx Metformin/locaserin 16 ○ ○ ○
Go GY19) C57BL/6J mouse M/9 HFD Yeoldahanso-tang: Pueraria lobata (Willd.) Ohwi, Angelica tenuissima Nakai, Scutellaria baicalensis Georgi, Playtycodon grandiflorum (Jacq), Angelicae Dahurica, Cimicifuga heracleifolia Kom, Raphanus sativa L. - 6 ○ ○ ○ ○
Kim DH20) C57BL/6J mouse M/- HFD Chaenomeles sinensis (Thouin) Koehne - 12 ○ ○ ○
Baek SY21) ob/ob mouse F/7 TI Gangji-hwan: Ephedra intermedia Schrenk et C. A. Meyer, Rheum palmatum L., Lithospermum erythrorhizon Siebold et Zuccarini - 10 ○ ○ ○
Song MY22) C57BL/6 mouse M/5 HFD Aconitum carmichaeli Debx. - 16 ○ ○ ○
Yoo HJ23) C57BL/6 mouse M/6 HFD Bangkeebokryeong-tang: Sinomenii Radix, Astragali Radix, Cinnamomi Ramulus, Hoele, Glycyrrhizae Radix Orlistat 4 ○ ○ ○
Kwak JY24) C57BL/6 mouse M/6 HFD Phaseolus angularis shell Orlistat 7 ○ ○ ○ ○
Tseng HH25) C57BL/6JNarl mouse M/7 HFD Ganoderma tsugae - 12 ○ ○ ○ ○
Akaki J26) C57BL/6J mouse M/5 HFD Bofutsusho-san: Angelicae Radix, Paeoniae Radix, Cnidii Rhizoma, Gardeniae Fructus, Forsythiae Fructus, Menthae Herba, Zingiberis Rhizoma, Schizonepetae Spica, Saposhnikoviae Radix, Ephedrae Herba, Rhei Rhizoma, Natrium Sulfricum, Atractylodis Rhizoma, Platycodi Radix, Scutellariae Radix, Glycyrrhizae Radix, Gypsum, Kasseki - 30 (d) ○ ○
Song MY27) C5BL/6 mouse M/5 HFD Atractylodes macrocephala Koidzumi Metformin 16 ○ ○ ○ ○
Kim MA28) C57BL/6 mouse, ob/ob mouse F/7 TI Geijibokryung-hwan: Cinnamomi Ramulus, Poria, Moutan Cortex, Paeoniae Radix, Persicae Seme) Gangji-hwan: Ephedrae Herba, Rhei Radix et Rhizoma, Arnebiae/ Lithospermi Radix - 10 ○ ○ ○
Jang SW29) C57BL/6J mouse -/9 HFD Jeoreongchajeonja-tang: Poria, Rhizoma Alismatis, Polyporus umbellatus, Semen Plantaginis, Anemarrhena asphodeloides Bunge, Gypsum, Saposhnikovia divaricata Schischkin, Schizonepeta tenuifolia Briquet, Rhizoma Notopterygii, Radix Angelicae Pubescentis Garcinia cambogia 7 ○ ○ ○ ○
Kim JM30) ICR mouse M/4 HFD Seungyangjeseup-tang: Atractylodis Rhizoma, Cimicifugae Rhizoma, Bupleuri Radix, Osterici Radix, Saposhnikoviae Radix, Massa Medicata Fermentata, Alismatis Rhizoma, Polyporus, Citri Pericarpium, Hordei Fructus Germinatus, Glycyrrhizae Radix Orlistat 4 ○ ○
Jeong MJ31) C57BL/6 mouse M/4 HFD Younggyechulgam-tang-ga Hwanggi: Poria, Cinnamomi Ramulus, Atractylodis Macrocephalae Rhizoma, Glycyrrhiza Radix, Astragali Radix Orlistat 5 ○ ○ ○
Cho EJ32) Sprague-Dawley rat M/6 HFD Daecheongryoung-tang: Gypsum, Ephedrae Herba, Armeniacae Semen, Cinnamomi Ramulus, Glycyrrhizae Radix, Zingiberis Rhizoma Crudus, Ziziphus jujuba - 6 ○ ○
Kim SY33) C57BL/6 mouse M/5 HFD Plantaginis asiaticae Folium Garcinia cambogia 6 ○ ○ ○
Kim SY34) C57BL/6 mouse M/5 HFD Plantaginis asiaticae Folium Garcinia cambogia 6 ○
Zhang C35) C57BL/6J mouse M/4 HFD Caulis Spatholobi - 13 ○ ○ ○ ○
Zhang H36) C57BL/6J mouse M/5-6 HFD Jinlida granules: Ginseng Radix et Rhizoma, Polygonati Rhizoma, Atractylodis Rhizoma, Sophorae Flavescentis Radix, Ophiopogonis Radix, Rehmanniae Radix, Polygoni Multiflori Radix Praeparata, Corni Fructus, Poria, Eupatorii Herba, Coptidis Rhizoma, Anemarrhenae Rhizoma, Epimedii Folium, Salviae Miltiorrhizae Radix et Rhizoma, Lycii Cortex, Puerariae Thomaonii Radix, Litchi Semen - 15 ○ ○ ○ ○
Buhlmann E37) Mouse -/4 HFD Pueraria montana var. lobata Ephedra herba 12 ○ ○ ○
Xiao S38) Sprague-Dawley rat M/- HFD Xiexin-tang: Rheum palmatum L., Scutellaria baicalensis Georgi, Coptis chinensis Franch. Simvastatin 4 ○ ○ ○ ○
Park JB39) C57BL/6J mouse M/4 HFD Citrus aurantium Linné - 8 ○ ○
Koh YM40) C57BL/6J mouse M/8 HFD Yangkyuksanwha-tang: Rehmannia glutinosa, Lonicera japonica Thunberg, Forsythia viridissima Lindley, Gardenia jasminoides Ellis, Mentha arvensis L. var. piperascens Malinvaud ex Holmes, Anemarrhena asphodeloides Bunge, Gypsum, Saposhnikovia divaricata Schischkin, Schizonepeta tenuifolia Briquet Garcinia cambogia 6 ○ ○ ○ ○
Park YJ41) C57BL/6N mouse M/8 HFD Tongbi-san: Cyperus rotundus L., Citrus unshiu Markovich, Poria cocos Orlistat 11 ○ ○ ○ ○
Kim TR42) C57BL/6 mouse M/4 HFD Banggihwnggi-tang-hap-yeonggyechulgam-tang: Astragali Radix, Atractylodis Rhizoma, Atractylodis Macrocephalae Rhizoma, Sinomenii Radix, Poria, Alismatis Rhizom, Plantaginis Semen, Cinnamomi Ramulus, Glycyrrhiza Radix Orlistat 7 ○ ○ ○ ○
Kim HR43) C57BL/6J mouse M/6 HFD Mixture of Atractylodes macrocephala Koidz. and Amomum villosum Lour. - 6 ○ ○ ○
Shin MH44) Sprague-Dawley rat M/6 HFD Pharbitidis Semen Bupropion/ naltrexone 8 ○ ○ ○
Kim MJ45) C57BL/6J mouse F/4 HFD, fructose water Crataegus pinnatifida Orlistat 7 ○ ○ ○
Wu F46) C57BL/6 mouse M/6 HFD Wumei-Wan: Mume Fructus, Asari Radix et Rhizoma, Zingiberis Rhizoma, Coptidis Rhizoma, Angelicae Sinensis Radix, Typhonii Rhizoma, Zanthoxyli Pericarpium, Cinnamomi Ramulus, Ginseng Radix et Rhizoma, Phellodendri Chinensis Cortex) - 4 ○ ○ ○ ○
Hwang SB47) C57BL/6 mouse M/5 HFD Nelumbinis Semen - 12 ○ ○ ○ ○
Lee SM48) C57BL/6J mouse M/6 HFHCD Yijin-tang: Pinellia ternata (Thunb.) Makino, Citrus unshiu Markovich, Poria cocos F.A. Wolf, Glycyrrhiza uralensis Fisch Simvastatin 6 ○ ○ ○ ○
Park YJ49) C57BL/6N mouse M/8 - Bojungchiseup-tang: Panax ginseng C. A. Meyer, Atractylodes macrocephala Koidzumi, Atractylodes chinensis Koidzumi, Citrus unshiu Markovich, Poria cocos Wolf, Liriope platyphylla Wang et Tang, Akebia quinata Decaisne, Angelica gigas Nakai, Scutellaria baicalensis Georgi, Magnolia obovata Thunberg, Cimicifuga heracleifolia Komarov - 11 ○ ○ ○ ○
Kim KJ50) C57BL/6 mouse M/4 HFD Unripe Rubus coreanus Miquel - 6/8/16 ○ ○ ○ ○
Jung SM51) C57BL/6 mouse M/5 HFD DM2: Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, Moutan Radicles Cortex Metformin 4 ○ ○ ○
Kim HR52) C57BL/6J mouse M/6 HFD Mixture of Atractylodes macrocephala and Amomum villosum - 6 ○ ○ ○
Sung YY53) C57BL/6J mouse M/4 HFD BS21: Phyllostachys pubescens, Scutellaria baicalensis Garcinia cambogia 8 ○ ○ ○ ○
Park JH54) C57BL/6N mouse M/5 HCD Amomum tsao-ko Crevost et Lemaire - 12 ○ ○ ○
Park YJ55) C57BL/6N mouse M/8 HFD Gambi-jung: Ephedra sinica Stapf, Coix lacryma-jobi L. var. ma-yuen, Castanea crenata Siebold et Zuccarini, Rehmannia glutinosa Liboschitz ex Steudel, Scgusabdra chinensis Baillon, Ophiopogon japonicas Ker-Gawler, Zingiber officinale Roscoe, Zizyphus jujube Miller var. spinose Hu ex H. F. Chou, Acorus gramineus Solander, Alisma orientale Juzepzuk, Pueraria lobate Ohwi, Ligusticum tenuissimum Kitagawa, Platy-codon grandiflourm A. De Candolle, Rheum tanguiticum Mzximowicz ex Balf. Orlistat or Ephedra sinica Stapf 9 ○ ○ ○ ○
Shin MR56) C57BL/6 mouse M/5 HFD Taraxacum coreanum Nakai Garcinia cambogia 5 ○ ○ ○ ○
Park YJ57) C57BL/6N mouse M/8 HFD Atractylodes chinensis Koidz. Orlistat 8 ○ ○ ○ ○
Jung SM58) C57BL/6 mouse M/6 HFD Clean-DM4: Coptidis Rhizoma, Salviae Miltiorrhizae Radix, Cinnamomi Cortex Metformin 4 ○ ○ ○
Kim SH59) Sprague-Dawley rat M/6 HFD Changbudodam-tang: Atractylodes chinensis, Cyperus rotundus, Citrus aurantum, Citrus unshiu, Poria cocos, Arisaema amurense, Glycyrrhiza uralensis, Triticum aestivum, Zingiber officinale Phentermine hydrochloride 7 ○ ○ ○
Choi JW60) C57BL/6 mouse M/4 HFD Achyranthis Radix - 6 ○ ○

HFD: high fat diet, M: male, F: female, TI: transformation induction, HFHCD: high fat and high cholesterol diet, HCD: high carbohydrate diet.
J Korean Med Obes Res 2022;22:54-76 https://doi.org/10.15429/jkomor.2022.22.1.54
© 2022 J Korean Med Obes Res