Fig. 4. Effects of C-DM4 extract on the histological changes of liver and pancreas tissues in high fat diet-induced obesity mice. The liver (A) and pancreas (C) tissues were stained with hematoxylin and eosin and observed under microscope (x200). The weights of liver (B) and pancreas (D) were measured in mice at 12 week. Data were presented as mean±standard deviation (n=5 per a group). *P<0.05, **P<0.01, and ***P<0.001 vs. control (a) or HFD group (b). Cont: normal group, HFD: high fat diet-induced diabetic control group, C-DM4: C-DM4 at 500 mg/kg-administrated group, Met: metformin-administrated group.